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Dead Cells is a 2D side-scrolling action platformer combining roguelike and Metroidvania design. Players control the Prisoner, an immortal creature that possesses corpses and fights through procedurally generated levels filled with mutated enemies. Combat centers on melee weapons, bows, traps, and dodging, with enemy patterns that reward careful observation. Death is permanent for each run, stripping the player of most collected items, though an in-game currency called Cells allows for purchasing upgrades that persist between attempts. Levels are assembled from pre-designed sections in randomized configurations, and progression through the game unlocks new traversal abilities via collectible Runes.